Acute toxicity via oral administration of naproxen in body mass gain and organs mass of female albino rats (Rattus rattus)

Abstract

Naproxen, 4,2-(6′-methoxy-2′-naphthyl)-propionic acid is a nonsteroidal anti-inflammatory drug (NSAID); as in recent toxicity research, the determination of danger has been demonstrated in rats with a curative dose compared to the human dose. Actually, it is used in both rheumatic and non-rheumatic inflammatory pain. In this study, repeated oral doses of naproxen were administered once daily. The research model consisted of 20 white rats. The four groups, each consisting of five individuals, received the drug for 28 days at the following doses: 500, 750, and 1000 mg/kg/day. Group 1 was the control group, receiving saline as a daily dose. Group 2 received 500 mg/kg each day, Group 3 received 750 mg/kg each day, and Group 4 received 1000 mg/kg each day. The rats were slaughtered after 28 days of treatment. After receiving treatment for 28 days, the rats were slaughtered, and the animals were weighed before and after the end of the period, as well as the vital organs (liver, kidney, and testicle), followed by statistical studies of the recorded weights. As a result of the drug's effect, weight was affected in a decreasing manner from the lowest dose to the highest according to the study program, and statistically significant differences were observed. Cases of hematuria were recorded, which led to damage and a sharp drop in weight. The harmful effects of naproxen are notable in the short term. Thus, this assay was conducted to certify the effect of naproxen on body weight gain as a primary criterion for harm in female rats.